Assay Detail
Functional
CHEMBL1034717
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Antiproliferative activity against human IGROV1 cells after 72 hrs
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | IGROV-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.52 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL538364 | — | — | 1 | 6.24 |
| CHEMBL557066 | — | — | 1 | 6.21 |
| CHEMBL561209 | — | — | 1 | 6.12 |
| CHEMBL551151 | — | — | 1 | 6.10 |
| CHEMBL552750 | — | — | 1 | 5.98 |
| CHEMBL538712 | — | — | 1 | 5.96 |
| CHEMBL538967 | — | — | 1 | 5.85 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.66 |
| CHEMBL539156 | — | — | 1 | 5.60 |
| CHEMBL538710 | — | — | 1 | 5.57 |
| CHEMBL561212 | — | — | 1 | 5.55 |
| CHEMBL556532 | — | — | 1 | 5.46 |
| CHEMBL565140 | — | — | 1 | 5.39 |
| CHEMBL561411 | — | — | 1 | 5.27 |
| CHEMBL556332 | — | — | 1 | 5.12 |
| CHEMBL551486 | — | — | 1 | 5.10 |
| CHEMBL541239 | — | — | 1 | 5.10 |
| CHEMBL562757 | — | — | 1 | 4.92 |
| CHEMBL538713 | — | — | 1 | 4.66 |
| CHEMBL551549 | — | — | 1 | 4.50 |
| CHEMBL555906 | — | — | 1 | - |
| CHEMBL554573 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL538364 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL557066 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL561209 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL551151 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL552750 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL538712 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL538967 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL539156 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL538710 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL561212 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL556532 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL565140 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL561411 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL556332 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL551486 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL541239 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL562757 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL538713 | — | IC50 | = | 22100.0 | nM | 4.66 |
| CHEMBL551549 | — | IC50 | = | 31900.0 | nM | 4.50 |
| CHEMBL555906 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL554573 | — | IC50 | - | — | - |