Review anchor
IGROV-1
CELL-LINE · Homo sapiens
As of 2026-09-13
Evidence Snapshot
IGROV-1
CHEMBL613984
CELL-LINE
Homo sapiens
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats IGROV-1 as ChEMBL target CHEMBL613984. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL613984
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-13
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why IGROV-1 matters
IGROV-1 is reviewed as IGROV-1; the current evidence base includes 37 approved drugs, 43310 compounds, and 1187 assays, with lead potency reaching pChEMBL 10.2.
Protein context
IGROV-1
IGROV-1
Review this target as IGROV-1.
Protein source · UniProt accession via ChEMBL component mappingDisease context
Disease signal
Disease relevance is not yet populated for this evidence card.
This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target recordActivity base
Portfolio and assay base
ChEMBL currently tracks 37 approved drugs, 43310 compounds, and 1187 assays for this target. The dominant activity type is IC50. CHEMBL96926 is the current potency anchor at pChEMBL 10.2.
Use CHEMBL96926 as the tractability anchor when discussing potency (pChEMBL 10.2).
Activity source · ChEMBL 36 via Core Engine
37 approved
pChEMBL 10.2
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why IGROV-1 matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
43310
Total Compounds
1187
Total Assays
37
Approved Drugs
IC50: 680.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL96926
|
10.2 | IC50 | — |
|
|
No preferred name
CHEMBL888
|
9.8 | IC50 | Approved |
|
|
No preferred name
CHEMBL94657
|
9.8 | IC50 | Clinical |
|
|
No preferred name
CHEMBL2158681
|
9.3 | IC50 | — |
|
|
No preferred name
CHEMBL150607
|
9.3 | IC50 | — |
Approved Drugs
| Structure | Compound | First Approval |
|---|---|---|
|
|
AFATINIB
CHEMBL1173655
|
2013 |
|
|
BOSUTINIB
CHEMBL288441
|
2012 |
|
|
VISMODEGIB
CHEMBL473417
|
2012 |
|
|
ROMIDEPSIN
CHEMBL343448
|
2009 |
|
|
TEMSIROLIMUS
CHEMBL1201182
|
2007 |
|
|
PEMETREXED
CHEMBL225072
|
2004 |
|
|
RALTITREXED
CHEMBL225071
|
1996 |
|
|
IRINOTECAN
CHEMBL481
|
1996 |
|
|
GEMCITABINE
CHEMBL888
|
1996 |
|
|
TOPOTECAN
CHEMBL84
|
1996 |
|
|
DOCETAXEL
CHEMBL3545252
|
1995 |
|
|
VINORELBINE
CHEMBL553025
|
1994 |
|
|
TRIMETREXATE
CHEMBL119
|
1993 |
|
|
PACLITAXEL
CHEMBL428647
|
1992 |
|
|
ETOPOSIDE
CHEMBL44657
|
1983 |
|
|
MITOMYCIN
CHEMBL105
|
1981 |
|
|
DOXORUBICIN
CHEMBL53463
|
1974 |
|
|
VINBLASTINE
CHEMBL159
|
1965 |
|
|
VINCRISTINE SULFATE
CHEMBL501867
|
1963 |
|
|
METHOTREXATE
CHEMBL34259
|
1953 |
Source Header