Assay Detail
ADMET
CHEMBL1035787
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Inhibition of CYP3A4 in human liver microsomes
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
3-amino-7-phthalazinylbenzoisoxazoles as a novel class of potent, selective, and orally available inhibitors of p38alpha mitogen-activated protein kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.28 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL495084 | — | — | 1 | 5.75 |
| CHEMBL524054 | — | — | 1 | 5.40 |
| CHEMBL495290 | — | — | 1 | 5.38 |
| CHEMBL523516 | — | — | 1 | 5.35 |
| CHEMBL495492 | — | — | 1 | 5.25 |
| CHEMBL522877 | — | — | 1 | 5.25 |
| CHEMBL495118 | — | — | 1 | 5.22 |
| CHEMBL495493 | — | — | 1 | 5.00 |
| CHEMBL494916 | — | — | 1 | 4.92 |
| CHEMBL494917 | — | — | 1 | - |
| CHEMBL522689 | — | — | 1 | - |
| CHEMBL494305 | — | — | 1 | - |
| CHEMBL493496 | — | — | 1 | - |
| CHEMBL492661 | — | — | 1 | - |
| CHEMBL521860 | — | — | 1 | - |
| CHEMBL523374 | — | — | 1 | - |
| CHEMBL493707 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL495084 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL524054 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL495290 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL523516 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL495492 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL522877 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL495118 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL495493 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL494916 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL494917 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL522689 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL494305 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL493496 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL492661 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL521860 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL523374 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL493707 | — | IC50 | - | — | - |