Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1037516

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Poliovirus infected in african green monkey Vero cells by SRB assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human enterovirus C
Cell Type Vero
Confidence 1 — Organism
Curated By Autocuration

Target

Enterovirus C (CHEMBL612462)
Type ORGANISM
Organism Enterovirus C

Publication

Synthesis and antiviral activity of beta-carboline derivatives bearing a substituted carbohydrazide at C-3 against poliovirus and herpes simplex virus (HSV-1).
Nazari Formagio AS, Santos PR, Zanoli K, Ueda-Nakamura T, Düsman Tonin LT, Nakamura CV, Sarragiotto MH.
Eur J Med Chem (2009) 44 : 4695 -4701
PubMed 19647908 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 19 5.88 6.06

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL570511 1 6.06
CHEMBL570510 1 6.06
CHEMBL570059 1 5.99
CHEMBL584953 1 5.71
CHEMBL569557 1 5.57
CHEMBL576070 1 -
CHEMBL572024 1 -
CHEMBL571146 1 -
CHEMBL578814 1 -
CHEMBL572026 1 -
CHEMBL570465 1 -
CHEMBL570466 1 -
CHEMBL569558 1 -
CHEMBL570954 1 -
CHEMBL569115 1 -
CHEMBL571359 1 -
CHEMBL572236 1 -
CHEMBL569338 1 -
CHEMBL583335 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL570511 EC50 = 870.0 nM 6.06
CHEMBL570510 EC50 = 870.0 nM 6.06
CHEMBL570059 EC50 = 1030.0 nM 5.99
CHEMBL584953 EC50 = 1950.0 nM 5.71
CHEMBL569557 EC50 = 2670.0 nM 5.57
CHEMBL576070 EC50 > 100000.0 nM -
CHEMBL572024 EC50 > 100000.0 nM -
CHEMBL571146 EC50 > 100000.0 nM -
CHEMBL578814 EC50 > 100000.0 nM -
CHEMBL572026 EC50 > 100000.0 nM -
CHEMBL570465 EC50 > 100000.0 nM -
CHEMBL570466 EC50 > 100000.0 nM -
CHEMBL569558 EC50 > 100000.0 nM -
CHEMBL570954 EC50 > 100000.0 nM -
CHEMBL569115 EC50 > 100000.0 nM -
CHEMBL571359 EC50 > 100000.0 nM -
CHEMBL572236 EC50 > 100000.0 nM -
CHEMBL569338 EC50 > 100000.0 nM -
CHEMBL583335 EC50 > 100000.0 nM -