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Compound Detail

CHEMBL570466

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COc1ccc(-c2nc(C(=O)N/N=C/c3ccccc3)cc3c2[nH]c2ccccc23)cc1

Basic Information

ChEMBL ID CHEMBL570466
Phase Preclinical
Structure Type MOL
InChI Key LEYQXDRSOGRLRT-JVWAILMASA-N
8
Targets
8
Activities
1
Assay Types
0
PK Parameters
12
Publications
0
Known Names

Molecular Properties

420.5
MW (Da)
5.16
ALogP
4
HBA
2
HBD
79.4
PSA (Ų)
0.30
QED
1
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H20N4O2
MW 420.47
Aromatic Rings 5
Heavy Atoms 32
NP-Likeness -0.83

Activity Summary

IC50 8 meas. best 5.49

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
K562
CHEMBL385
IC50 5.49 5.49 3220.0 1
NCI-H460
CHEMBL396
IC50 5.46 5.46 3450.0 1
UACC-62
CHEMBL614610
IC50 5.46 5.46 3450.0 1
NON-PROTEIN TARGET
CHEMBL3879801
IC50 4.58 4.58 26530.0 1
OVCAR
CHEMBL614212
IC50 4.49 4.49 32280.0 1
HT-29
CHEMBL384
IC50 4.44 4.44 35990.0 1
MCF7
CHEMBL387
IC50 4.44 4.44 35990.0 1
786-0
CHEMBL613102
IC50 4.03 4.03 93370.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

Data from ChEMBL 36 via Core Engine