Assay Detail
Functional
CHEMBL1918156
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Antitumor activity against human OVCAR cells by SRB colorimetric assay
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | OVCAR |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antitumor activity of β-carboline 3-(substituted-carbohydrazide) derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 50 | 5.04 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL569115 | — | — | 1 | 6.72 |
| CHEMBL569338 | — | — | 1 | 6.43 |
| CHEMBL569557 | — | — | 1 | 5.90 |
| CHEMBL570059 | — | — | 1 | 5.90 |
| CHEMBL572024 | — | — | 1 | 5.74 |
| CHEMBL583335 | — | — | 1 | 5.69 |
| CHEMBL578814 | — | — | 1 | 5.55 |
| CHEMBL1917659 | — | — | 1 | 5.34 |
| CHEMBL1917654 | — | — | 1 | 5.21 |
| CHEMBL1917657 | — | — | 1 | 5.13 |
| CHEMBL570510 | — | — | 1 | 5.00 |
| CHEMBL584953 | — | — | 1 | 4.98 |
| CHEMBL1917828 | — | — | 1 | 4.95 |
| CHEMBL1917660 | — | — | 1 | 4.89 |
| CHEMBL1917663 | — | — | 1 | 4.88 |
| CHEMBL571146 | — | — | 1 | 4.84 |
| CHEMBL1917666 | — | — | 1 | 4.68 |
| CHEMBL571359 | — | — | 1 | 4.67 |
| CHEMBL1914493 | — | — | 1 | 4.58 |
| CHEMBL570466 | — | — | 1 | 4.49 |
| CHEMBL1917833 | — | — | 1 | 4.39 |
| CHEMBL1917655 | — | — | 1 | 4.33 |
| CHEMBL576070 | — | — | 1 | 4.29 |
| CHEMBL1917835 | — | — | 1 | 4.19 |
| CHEMBL570511 | — | — | 1 | 4.12 |
| CHEMBL1917661 | — | — | 1 | 4.11 |
| CHEMBL572236 | — | — | 1 | - |
| CHEMBL1917671 | — | — | 1 | - |
| CHEMBL569558 | — | — | 1 | - |
| CHEMBL1917658 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL569115 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL569338 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL570059 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL569557 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL572024 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL583335 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL578814 | — | IC50 | = | 2840.0 | nM | 5.55 |
| CHEMBL1917659 | — | IC50 | = | 4550.0 | nM | 5.34 |
| CHEMBL1917654 | — | IC50 | = | 6140.0 | nM | 5.21 |
| CHEMBL1917657 | — | IC50 | = | 7430.0 | nM | 5.13 |
| CHEMBL570510 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL584953 | — | IC50 | = | 10560.0 | nM | 4.98 |
| CHEMBL1917828 | — | IC50 | = | 11190.0 | nM | 4.95 |
| CHEMBL1917660 | — | IC50 | = | 12750.0 | nM | 4.89 |
| CHEMBL1917663 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL571146 | — | IC50 | = | 14420.0 | nM | 4.84 |
| CHEMBL1917666 | — | IC50 | = | 20750.0 | nM | 4.68 |
| CHEMBL571359 | — | IC50 | = | 21400.0 | nM | 4.67 |
| CHEMBL1914493 | — | IC50 | = | 26370.0 | nM | 4.58 |
| CHEMBL570466 | — | IC50 | = | 32280.0 | nM | 4.49 |
| CHEMBL1917833 | — | IC50 | = | 40450.0 | nM | 4.39 |
| CHEMBL1917655 | — | IC50 | = | 46730.0 | nM | 4.33 |
| CHEMBL576070 | — | IC50 | = | 51040.0 | nM | 4.29 |
| CHEMBL1917835 | — | IC50 | = | 64170.0 | nM | 4.19 |
| CHEMBL570511 | — | IC50 | = | 75910.0 | nM | 4.12 |
| CHEMBL1917661 | — | IC50 | = | 78050.0 | nM | 4.11 |
| CHEMBL570465 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1917838 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1917837 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1917836 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1917834 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1917832 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1917831 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1917830 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1917829 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1917827 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1917656 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL572026 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL572236 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1917839 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1917670 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1917669 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1917668 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1917667 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1917665 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1917664 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1917662 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1917658 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL569558 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1917671 | — | IC50 | > | 100000.0 | nM | - |