Assay Detail
Binding
CHEMBL1039634
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]ketanserin from 5HT2A receptor in rat cortex
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.67 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18772 | QUIPAZINE | 2.0 | 1 | 6.10 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 5.90 |
| CHEMBL582992 | — | — | 1 | 5.01 |
| CHEMBL566522 | — | — | 1 | - |
| CHEMBL571046 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18772 | QUIPAZINE | Ki | = | 794.0 | nM | 6.10 |
| CHEMBL39 | SEROTONIN | Ki | = | 1258.0 | nM | 5.90 |
| CHEMBL582992 | — | Ki | = | 9806.0 | nM | 5.01 |
| CHEMBL566522 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL571046 | — | Ki | > | 10000.0 | nM | - |