Assay Detail
Binding
CHEMBL1039873
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of GS-red from human glucocorticoid receptor by fluorescent polarization assay
39
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Novel synthesis of the hexahydroimidazo[1,5b]isoquinoline scaffold: application to the synthesis of glucocorticoid receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 39 | 8.35 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL310570 | — | — | 1 | 9.10 |
| CHEMBL569044 | — | — | 1 | 9.00 |
| CHEMBL569544 | — | — | 1 | 9.00 |
| CHEMBL566600 | — | — | 1 | 9.00 |
| CHEMBL384467 | DEXAMETHASONE | 4.0 | 1 | 8.92 |
| CHEMBL572329 | — | — | 1 | 8.82 |
| CHEMBL572356 | — | — | 1 | 8.74 |
| CHEMBL572355 | — | — | 1 | 8.70 |
| CHEMBL584258 | — | — | 1 | 8.70 |
| CHEMBL577945 | — | — | 1 | 8.70 |
| CHEMBL576472 | — | — | 1 | 8.70 |
| CHEMBL567027 | — | — | 1 | 8.70 |
| CHEMBL583625 | — | — | 1 | 8.70 |
| CHEMBL567028 | — | — | 1 | 8.70 |
| CHEMBL566823 | — | — | 1 | 8.70 |
| CHEMBL572357 | — | — | 1 | 8.60 |
| CHEMBL566575 | — | — | 1 | 8.60 |
| CHEMBL311662 | — | — | 1 | 8.60 |
| CHEMBL584522 | — | — | 1 | 8.59 |
| CHEMBL569290 | — | — | 1 | 8.52 |
| CHEMBL572212 | — | — | 1 | 8.51 |
| CHEMBL583629 | — | — | 1 | 8.41 |
| CHEMBL572330 | — | — | 1 | 8.40 |
| CHEMBL565320 | — | — | 1 | 8.37 |
| CHEMBL569061 | — | — | 1 | 8.28 |
| CHEMBL569543 | — | — | 4 | 8.15 |
| CHEMBL566387 | — | — | 1 | 8.10 |
| CHEMBL566391 | — | — | 2 | 8.10 |
| CHEMBL567237 | — | — | 1 | 8.05 |
| CHEMBL569100 | — | — | 1 | 7.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL310570 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL569544 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL569044 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL566600 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL384467 | DEXAMETHASONE | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL572329 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL572356 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL572355 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL567027 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL576472 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL577945 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL584258 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL567028 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL583625 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL566823 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL572357 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL311662 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL566575 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL584522 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL569290 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL572212 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL583629 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL572330 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL565320 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL569061 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL569543 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL566391 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL566387 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL567237 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL566391 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL569100 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL583858 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL583858 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL583859 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL566818 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL569543 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL568868 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL569543 | — | Ki | = | 134.0 | nM | 6.87 |
| CHEMBL569543 | — | Ki | > | 1150.0 | nM | - |