Compound Detail
CHEMBL572356
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Basic Information
| ChEMBL ID | CHEMBL572356 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GSBXDPQKEHNRQR-ZROWWJAZSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
444.6
MW (Da)
6.71
ALogP
4
HBA
1
HBD
38.0
PSA (Ų)
0.38
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 8.74
Ki 1 meas. best 8.74
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glucocorticoid receptor CHEMBL2034 | EC50 | 8.74 | 8.74 | 1.8 | 1 |
| Glucocorticoid receptor CHEMBL2034 | Ki | 8.74 | 8.74 | 1.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor | EC50 | = | 1.8 | nM | 8.74 | Transrepression activity at glucocorticoid receptor expressed in human A549 cell... | 20047280 |
| Glucocorticoid receptor | Ki | = | 1.8 | nM | 8.74 | Displacement of GS-red from human glucocorticoid receptor by fluorescent polariz... | 20047280 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20047280 | 10.1021/jm901551w | Glucocorticoid receptor | 3 |
Data from ChEMBL 36 via Core Engine