Assay Detail
Binding
CHEMBL1040199
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assay
22
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Tetrahydrocarbazole-based serotonin reuptake inhibitor/dopamine D2 partial agonists for the potential treatment of schizophrenia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 7.50 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL566396 | — | — | 1 | 9.40 |
| CHEMBL1508 | ESCITALOPRAM | 4.0 | 1 | 9.00 |
| CHEMBL569251 | — | — | 2 | 9.00 |
| CHEMBL567454 | — | — | 1 | 8.52 |
| CHEMBL566379 | — | — | 2 | 8.40 |
| CHEMBL566356 | — | — | 1 | 8.10 |
| CHEMBL569476 | — | — | 1 | 8.00 |
| CHEMBL568538 | — | — | 1 | 7.68 |
| CHEMBL569513 | — | — | 2 | 7.66 |
| CHEMBL1237165 | — | — | 1 | 7.62 |
| CHEMBL565935 | — | — | 1 | 7.60 |
| CHEMBL566172 | — | — | 1 | 7.39 |
| CHEMBL566380 | — | — | 1 | 7.21 |
| CHEMBL568103 | — | — | 1 | 7.21 |
| CHEMBL1237149 | — | — | 1 | 6.34 |
| CHEMBL571464 | — | — | 1 | 5.94 |
| CHEMBL565553 | — | — | 1 | 5.92 |
| CHEMBL2094011 | — | — | 1 | 5.33 |
| CHEMBL566155 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL566396 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL1508 | ESCITALOPRAM | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL569251 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL567454 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL566379 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL569251 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL566356 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL569476 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL566379 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL568538 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL569513 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL1237165 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL565935 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL569513 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL566172 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL568103 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL566380 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL1237149 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL571464 | — | Ki | = | 1140.0 | nM | 5.94 |
| CHEMBL565553 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL2094011 | — | Ki | = | 4700.0 | nM | 5.33 |
| CHEMBL566155 | — | Ki | = | 5200.0 | nM | 5.28 |