Assay Detail
Functional
CHEMBL1040394
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Immunomodulatory activity in polymorphoneutrophils assessed as inhibition of luminol-induced oxidative burst by chemiluminescence assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | Neutrophil |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Oxidative burst inhibitory and cytotoxic indoloquinazoline and furoquinoline alkaloids from Oricia suaveolens.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.59 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | 4.92 |
| CHEMBL574554 | QUINOSUAVEOLINE B | — | 1 | 4.84 |
| CHEMBL572482 | TECLEAVERDOORNINE | — | 1 | 4.67 |
| CHEMBL574332 | ORISUAVEOLINE B | — | 1 | 4.65 |
| CHEMBL312248 | — | — | 1 | 4.56 |
| CHEMBL21396 | SKIMMIANINE | — | 1 | 4.45 |
| CHEMBL517449 | LIMONIN | — | 1 | 4.42 |
| CHEMBL278779 | KOKUSAGININE | — | 1 | 4.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL521 | IBUPROFEN | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL574554 | QUINOSUAVEOLINE B | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL572482 | TECLEAVERDOORNINE | IC50 | = | 21200.0 | nM | 4.67 |
| CHEMBL574332 | ORISUAVEOLINE B | IC50 | = | 22400.0 | nM | 4.65 |
| CHEMBL312248 | — | IC50 | = | 27400.0 | nM | 4.56 |
| CHEMBL21396 | SKIMMIANINE | IC50 | = | 35500.0 | nM | 4.45 |
| CHEMBL517449 | LIMONIN | IC50 | = | 38200.0 | nM | 4.42 |
| CHEMBL278779 | KOKUSAGININE | IC50 | = | 61800.0 | nM | 4.21 |