Assay Detail
Binding
CHEMBL1043294
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Displacement of [3H]prazosin from human adrenergic beta2 receptor V117C mutant expressed in CHO cell membrane
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural basis of the selectivity of the beta(2)-adrenergic receptor for fluorinated catecholamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 4.40 | 4.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL40317 | — | — | 1 | 4.40 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | - |
| CHEMBL295072 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL40317 | — | Ki | = | 39800.0 | nM | 4.40 |
| CHEMBL1437 | NOREPINEPHRINE | Ki | = | 217000.0 | nM | - |
| CHEMBL295072 | — | Ki | > | 2000000.0 | nM | - |