Assay Detail
Binding
CHEMBL1043589
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Displacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membrane
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Type-1 angiotensin II receptor A (CHEMBL329) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Design, synthesis, and docking studies of novel benzimidazoles for the treatment of metabolic syndrome.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.49 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1017 | TELMISARTAN | 4.0 | 1 | 9.64 |
| CHEMBL566614 | — | — | 1 | 7.87 |
| CHEMBL567898 | — | — | 1 | 5.79 |
| CHEMBL572276 | — | — | 1 | 5.65 |
| CHEMBL571763 | — | — | 1 | 5.60 |
| CHEMBL567897 | — | — | 1 | 5.55 |
| CHEMBL567054 | — | — | 1 | 5.30 |
| CHEMBL567063 | — | — | 1 | - |
| CHEMBL567689 | — | — | 1 | - |
| CHEMBL565793 | — | — | 1 | - |
| CHEMBL565379 | — | — | 1 | - |
| CHEMBL567269 | — | — | 1 | - |
| CHEMBL584704 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1017 | TELMISARTAN | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL566614 | — | Ki | = | 13.4 | nM | 7.87 |
| CHEMBL567898 | — | Ki | = | 1618.0 | nM | 5.79 |
| CHEMBL572276 | — | Ki | = | 2226.0 | nM | 5.65 |
| CHEMBL571763 | — | Ki | = | 2534.0 | nM | 5.60 |
| CHEMBL567897 | — | Ki | = | 2840.0 | nM | 5.55 |
| CHEMBL567054 | — | Ki | = | 5060.0 | nM | 5.30 |
| CHEMBL567063 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL567689 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL565793 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL565379 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL567269 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL584704 | — | Ki | > | 10000.0 | nM | - |