Assay Detail
Binding
CHEMBL1043671
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Displacement of [3H]ketanserin from 5HT2A receptor in rat cerebral cortex after 20 mins by liquid scintillation counting
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and preliminary pharmacological evaluation of imidazo[2,1-f]purine-2,4-dione derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 6.47 | 7.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL566890 | — | — | 1 | 7.04 |
| CHEMBL195047 | — | — | 1 | 6.53 |
| CHEMBL567496 | — | — | 1 | 6.39 |
| CHEMBL328292 | — | — | 1 | 6.31 |
| CHEMBL566235 | — | — | 1 | 6.09 |
| CHEMBL585105 | — | — | 1 | - |
| CHEMBL565423 | — | — | 1 | - |
| CHEMBL585300 | — | — | 1 | - |
| CHEMBL585503 | — | — | 1 | - |
| CHEMBL565405 | — | — | 1 | - |
| CHEMBL584814 | — | — | 1 | - |
| CHEMBL566022 | — | — | 1 | - |
| CHEMBL566227 | — | — | 1 | - |
| CHEMBL566891 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL566890 | — | Ki | = | 91.5 | nM | 7.04 |
| CHEMBL195047 | — | Ki | = | 297.0 | nM | 6.53 |
| CHEMBL567496 | — | Ki | = | 403.0 | nM | 6.39 |
| CHEMBL328292 | — | Ki | = | 486.0 | nM | 6.31 |
| CHEMBL566235 | — | Ki | = | 813.5 | nM | 6.09 |
| CHEMBL585105 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL565423 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL585300 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL585503 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL565405 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL584814 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL566022 | — | Ki | - | — | - | |
| CHEMBL566227 | — | Ki | - | — | - | |
| CHEMBL566891 | — | Ki | - | — | - |