Assay Detail
Functional
CHEMBL1043790
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Antimalarial activity against Plasmodium falciparum W2mef schizont form by hoechst 33342-thiazole orange stain based flow cytometry assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Addressing the malaria drug resistance challenge using flow cytometry to discover new antimalarials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.66 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 8.10 |
| CHEMBL416956 | MEFLOQUINE | 4.0 | 1 | 7.36 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.16 |
| CHEMBL261641 | — | — | 1 | 6.50 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 6.42 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 6.14 |
| CHEMBL175691 | RILPIVIRINE | 4.0 | 1 | 5.92 |
| CHEMBL572196 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL416956 | MEFLOQUINE | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL261641 | — | IC50 | = | 317.0 | nM | 6.50 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 376.0 | nM | 6.42 |
| CHEMBL308954 | ETRAVIRINE | IC50 | = | 716.0 | nM | 6.14 |
| CHEMBL175691 | RILPIVIRINE | IC50 | = | 1207.0 | nM | 5.92 |
| CHEMBL572196 | — | IC50 | = | 1998.0 | nM | 5.70 |