Assay Detail
Binding
CHEMBL1044081
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human SERT expressed in JAR cells
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | JAR |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-activity relationships of the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ol series of monoamine reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.55 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 8.03 |
| CHEMBL576542 | — | — | 1 | 7.85 |
| CHEMBL579244 | — | — | 1 | 7.32 |
| CHEMBL572927 | — | — | 1 | 7.32 |
| CHEMBL572917 | — | — | 1 | 7.28 |
| CHEMBL577597 | — | — | 1 | 7.11 |
| CHEMBL566958 | — | — | 1 | 7.10 |
| CHEMBL572951 | — | — | 1 | 6.95 |
| CHEMBL575132 | — | — | 1 | 6.76 |
| CHEMBL575133 | — | — | 1 | 6.68 |
| CHEMBL584152 | — | — | 1 | 6.66 |
| CHEMBL574921 | — | — | 1 | 6.64 |
| CHEMBL578841 | — | — | 1 | 6.58 |
| CHEMBL576145 | — | — | 1 | 6.46 |
| CHEMBL562476 | — | — | 1 | 6.45 |
| CHEMBL577825 | — | — | 1 | 6.42 |
| CHEMBL566957 | — | — | 1 | 6.40 |
| CHEMBL566090 | — | — | 1 | 6.38 |
| CHEMBL576170 | — | — | 1 | 6.36 |
| CHEMBL577598 | — | — | 1 | 6.33 |
| CHEMBL573667 | — | — | 1 | 6.31 |
| CHEMBL583411 | — | — | 1 | 6.28 |
| CHEMBL574920 | — | — | 1 | 6.26 |
| CHEMBL575535 | — | — | 1 | 6.26 |
| CHEMBL575546 | — | — | 1 | 6.20 |
| CHEMBL577612 | — | — | 1 | 6.13 |
| CHEMBL576758 | — | — | 1 | 6.08 |
| CHEMBL575753 | — | — | 1 | 6.06 |
| CHEMBL582894 | — | — | 1 | 6.05 |
| CHEMBL577565 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41 | FLUOXETINE | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL576542 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL579244 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL572927 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL572917 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL577597 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL566958 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL572951 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL575132 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL575133 | — | IC50 | = | 207.0 | nM | 6.68 |
| CHEMBL584152 | — | IC50 | = | 221.0 | nM | 6.66 |
| CHEMBL574921 | — | IC50 | = | 228.0 | nM | 6.64 |
| CHEMBL578841 | — | IC50 | = | 266.0 | nM | 6.58 |
| CHEMBL576145 | — | IC50 | = | 343.0 | nM | 6.46 |
| CHEMBL562476 | — | IC50 | = | 358.0 | nM | 6.45 |
| CHEMBL577825 | — | IC50 | = | 377.0 | nM | 6.42 |
| CHEMBL566957 | — | IC50 | = | 398.0 | nM | 6.40 |
| CHEMBL566090 | — | IC50 | = | 417.0 | nM | 6.38 |
| CHEMBL576170 | — | IC50 | = | 441.0 | nM | 6.36 |
| CHEMBL577598 | — | IC50 | = | 473.0 | nM | 6.33 |
| CHEMBL573667 | — | IC50 | = | 491.0 | nM | 6.31 |
| CHEMBL583411 | — | IC50 | = | 527.0 | nM | 6.28 |
| CHEMBL574920 | — | IC50 | = | 547.0 | nM | 6.26 |
| CHEMBL575535 | — | IC50 | = | 554.0 | nM | 6.26 |
| CHEMBL575546 | — | IC50 | = | 626.0 | nM | 6.20 |
| CHEMBL577612 | — | IC50 | = | 748.0 | nM | 6.13 |
| CHEMBL576758 | — | IC50 | = | 834.0 | nM | 6.08 |
| CHEMBL575753 | — | IC50 | = | 865.0 | nM | 6.06 |
| CHEMBL582894 | — | IC50 | = | 882.0 | nM | 6.05 |
| CHEMBL577565 | — | IC50 | = | 1003.0 | nM | 6.00 |
| CHEMBL583113 | — | IC50 | = | 1333.0 | nM | 5.88 |
| CHEMBL575131 | — | IC50 | = | 1366.0 | nM | 5.87 |
| CHEMBL577138 | — | IC50 | = | 2184.0 | nM | 5.66 |