Assay Detail
Functional
CHEMBL1044260
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Cytotoxicity against human Jurkat cells after 72 hrs by XTT assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel semisynthetic derivatives of betulin and betulinic acid with cytotoxic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 8.06 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL607802 | — | — | 1 | 8.85 |
| CHEMBL607803 | — | — | 1 | 8.64 |
| CHEMBL607515 | — | — | 1 | 8.28 |
| CHEMBL592972 | — | — | 1 | 8.22 |
| CHEMBL607804 | — | — | 1 | 8.15 |
| CHEMBL609466 | — | — | 1 | 8.09 |
| CHEMBL607799 | — | — | 1 | 8.00 |
| CHEMBL607514 | — | — | 1 | 7.96 |
| CHEMBL607800 | — | — | 1 | 7.91 |
| CHEMBL607801 | — | — | 1 | 7.86 |
| CHEMBL592973 | — | — | 1 | 7.79 |
| CHEMBL602387 | — | — | 1 | 7.79 |
| CHEMBL592974 | — | — | 1 | 7.70 |
| CHEMBL269277 | BETULINIC ACID | 1.0 | 1 | 7.57 |
| CHEMBL609465 | — | — | 1 | - |
| CHEMBL607516 | — | — | 1 | - |
| CHEMBL592971 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL607802 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL607803 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL607515 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL592972 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL607804 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL609466 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL607799 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL607514 | — | IC50 | = | 11.1 | nM | 7.96 |
| CHEMBL607800 | — | IC50 | = | 12.2 | nM | 7.91 |
| CHEMBL607801 | — | IC50 | = | 13.7 | nM | 7.86 |
| CHEMBL592973 | — | IC50 | = | 16.2 | nM | 7.79 |
| CHEMBL602387 | — | IC50 | = | 16.3 | nM | 7.79 |
| CHEMBL592974 | — | IC50 | = | 20.2 | nM | 7.70 |
| CHEMBL269277 | BETULINIC ACID | IC50 | = | 26.9 | nM | 7.57 |
| CHEMBL609465 | — | IC50 | > | 30.0 | nM | - |
| CHEMBL607516 | — | IC50 | > | 30.0 | nM | - |
| CHEMBL592971 | — | IC50 | > | 30.0 | nM | - |