Assay Detail
Binding
CHEMBL1044455
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Inhibition of human carbonic anhydrase 5A by stopped flow CO2 hydration assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Carbonic anhydrase 5A, mitochondrial (CHEMBL4789) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 5.12 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL567544 | — | — | 1 | 5.80 |
| CHEMBL577123 | — | — | 1 | 5.77 |
| CHEMBL12567 | — | — | 1 | 5.48 |
| CHEMBL568416 | — | — | 1 | 5.41 |
| CHEMBL83294 | COUMARIN-3-CARBOXYLIC ACID | — | 1 | 5.35 |
| CHEMBL571738 | — | — | 1 | 5.33 |
| CHEMBL568348 | — | — | 1 | 5.33 |
| CHEMBL49732 | HERNIARIN | — | 1 | 5.29 |
| CHEMBL571519 | — | — | 1 | 5.11 |
| CHEMBL578167 | — | — | 1 | 5.07 |
| CHEMBL567139 | — | — | 1 | 5.07 |
| CHEMBL6466 | COUMARIN | 4.0 | 1 | 5.03 |
| CHEMBL572366 | — | — | 1 | 4.80 |
| CHEMBL191528 | ETHOXYCOUMARIN | — | 1 | 4.53 |
| CHEMBL567896 | — | — | 1 | 4.31 |
| CHEMBL568516 | 7-PROPOXYCOUMARIN | — | 1 | 4.26 |
| CHEMBL568417 | — | — | 1 | - |
| CHEMBL568173 | — | — | 1 | - |
| CHEMBL568385 | — | — | 1 | - |
| CHEMBL145781 | 7-BENZYLOXYCOUMARIN | — | 1 | - |
| CHEMBL571514 | 7-BUTOXYCOUMARIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL567544 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL577123 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL12567 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL568416 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL83294 | COUMARIN-3-CARBOXYLIC ACID | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL571738 | — | Ki | = | 4700.0 | nM | 5.33 |
| CHEMBL568348 | — | Ki | = | 4700.0 | nM | 5.33 |
| CHEMBL49732 | HERNIARIN | Ki | = | 5100.0 | nM | 5.29 |
| CHEMBL571519 | — | Ki | = | 7700.0 | nM | 5.11 |
| CHEMBL578167 | — | Ki | = | 8500.0 | nM | 5.07 |
| CHEMBL567139 | — | Ki | = | 8600.0 | nM | 5.07 |
| CHEMBL6466 | COUMARIN | Ki | = | 9400.0 | nM | 5.03 |
| CHEMBL572366 | — | Ki | = | 15900.0 | nM | 4.80 |
| CHEMBL191528 | ETHOXYCOUMARIN | Ki | = | 29600.0 | nM | 4.53 |
| CHEMBL567896 | — | Ki | = | 48600.0 | nM | 4.31 |
| CHEMBL568516 | 7-PROPOXYCOUMARIN | Ki | = | 54500.0 | nM | 4.26 |
| CHEMBL568417 | — | Ki | > | 500000.0 | nM | - |
| CHEMBL568173 | — | Ki | > | 500000.0 | nM | - |
| CHEMBL568385 | — | Ki | = | 167400.0 | nM | - |
| CHEMBL145781 | 7-BENZYLOXYCOUMARIN | Ki | > | 500000.0 | nM | - |
| CHEMBL571514 | 7-BUTOXYCOUMARIN | Ki | > | 500000.0 | nM | - |