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Assay Detail

CHEMBL1044682

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Inhibition of human CYP2C9
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Cytochrome P450 2C9 (CHEMBL3397)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Alkyl-bridged substituted 8-arylquinolines as highly potent PDE IV inhibitors.
Lacombe P, Chauret N, Claveau D, Day S, Deschênes D, Dubé D, Gallant M, Girard Y, Huang Z, Laliberté F, Lévesque JF, Liu S, Macdonald D, Mancini JA, Masson P, Nicholson DW, Nicoll-Griffith DA, Salem M, Styhler A, Young RN.
Bioorg Med Chem Lett (2009) 19 : 5266 -5269
PubMed 19640717 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 5.69 6.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL571022 1 6.70
CHEMBL372575 1 6.70
CHEMBL570839 1 6.70
CHEMBL565558 1 6.22
CHEMBL586818 1 6.16
CHEMBL568232 1 5.82
CHEMBL1204128 1 5.68
CHEMBL1204129 1 5.55
CHEMBL567585 1 5.44
CHEMBL579266 1 5.44
CHEMBL1204130 1 5.43
CHEMBL571060 1 5.42
CHEMBL1204131 1 5.42
CHEMBL570939 1 5.41
CHEMBL585566 1 5.35
CHEMBL584475 1 5.34
CHEMBL591662 1 5.19
CHEMBL578359 1 5.16
CHEMBL568446 1 4.94

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL571022 IC50 = 200.0 nM 6.70
CHEMBL372575 IC50 = 200.0 nM 6.70
CHEMBL570839 IC50 = 200.0 nM 6.70
CHEMBL565558 IC50 = 600.0 nM 6.22
CHEMBL586818 IC50 = 700.0 nM 6.16
CHEMBL568232 IC50 = 1500.0 nM 5.82
CHEMBL1204128 IC50 = 2100.0 nM 5.68
CHEMBL1204129 IC50 = 2800.0 nM 5.55
CHEMBL567585 IC50 = 3600.0 nM 5.44
CHEMBL579266 IC50 = 3600.0 nM 5.44
CHEMBL1204130 IC50 = 3700.0 nM 5.43
CHEMBL571060 IC50 = 3800.0 nM 5.42
CHEMBL1204131 IC50 = 3800.0 nM 5.42
CHEMBL570939 IC50 = 3900.0 nM 5.41
CHEMBL585566 IC50 = 4500.0 nM 5.35
CHEMBL584475 IC50 = 4600.0 nM 5.34
CHEMBL591662 IC50 = 6400.0 nM 5.19
CHEMBL578359 IC50 = 6900.0 nM 5.16
CHEMBL568446 IC50 = 11400.0 nM 4.94