Assay Detail
Functional
CHEMBL1044758
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Antitrypanosomal activity against Trypanosoma cruzi Tulahuen infected in mouse 3T3 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Cell Type | NIH3T3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Isoquinoline-based analogs of the cancer drug clinical candidate tipifarnib as anti-Trypanosoma cruzi agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 8.64 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1397 | POSACONAZOLE | 4.0 | 1 | 9.52 |
| CHEMBL583404 | — | — | 1 | 9.30 |
| CHEMBL567210 | — | — | 1 | 9.05 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 8.40 |
| CHEMBL566126 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1397 | POSACONAZOLE | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL583404 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL567210 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL289228 | TIPIFARNIB | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL566126 | — | EC50 | = | 120.0 | nM | 6.92 |