Assay Detail
ADMET
CHEMBL1045201
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Inhibition of human CYP2C9
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and in vitro DMPK profiling of a 1,2-dioxolane-based library with activity against Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 5.46 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL565360 | — | — | 1 | 5.66 |
| CHEMBL567169 | — | — | 1 | 5.48 |
| CHEMBL577694 | — | — | 1 | 5.47 |
| CHEMBL572184 | — | — | 1 | 5.43 |
| CHEMBL565362 | — | — | 1 | 5.41 |
| CHEMBL565983 | — | — | 1 | 5.40 |
| CHEMBL565361 | — | — | 1 | 5.38 |
| CHEMBL585191 | — | — | 1 | - |
| CHEMBL579200 | — | — | 1 | - |
| CHEMBL567582 | — | — | 1 | - |
| CHEMBL568438 | — | — | 1 | - |
| CHEMBL579016 | — | — | 1 | - |
| CHEMBL462360 | — | — | 1 | - |
| CHEMBL568470 | — | — | 1 | - |
| CHEMBL576457 | — | — | 1 | - |
| CHEMBL584678 | — | — | 1 | - |
| CHEMBL578968 | — | — | 1 | - |
| CHEMBL579199 | — | — | 1 | - |
| CHEMBL584886 | — | — | 1 | - |
| CHEMBL568695 | — | — | 1 | - |
| CHEMBL565949 | — | — | 1 | - |
| CHEMBL568243 | — | — | 1 | - |
| CHEMBL583004 | — | — | 1 | - |
| CHEMBL579258 | — | — | 1 | - |
| CHEMBL578579 | — | — | 1 | - |
| CHEMBL578578 | — | — | 1 | - |
| CHEMBL577042 | — | — | 1 | - |
| CHEMBL568472 | — | — | 1 | - |
| CHEMBL578588 | — | — | 1 | - |
| CHEMBL568471 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL565360 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL567169 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL577694 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL572184 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL565362 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL565983 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL565361 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL576457 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL578594 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL584678 | — | IC50 | - | — | - | |
| CHEMBL578968 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL579199 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL579200 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL583442 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL568242 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL567375 | — | IC50 | - | — | - | |
| CHEMBL568456 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL576658 | — | IC50 | - | — | - | |
| CHEMBL567374 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL577470 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL578547 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL567376 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL584813 | — | IC50 | - | — | - | |
| CHEMBL568444 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL568243 | — | IC50 | - | — | - | |
| CHEMBL568471 | — | IC50 | - | — | - | |
| CHEMBL578588 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL568472 | — | IC50 | - | — | - | |
| CHEMBL577042 | — | IC50 | - | — | - | |
| CHEMBL578578 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL578579 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL579258 | — | IC50 | - | — | - | |
| CHEMBL583004 | — | IC50 | - | — | - | |
| CHEMBL568470 | — | IC50 | - | — | - | |
| CHEMBL565949 | — | IC50 | - | — | - | |
| CHEMBL568695 | — | IC50 | - | — | - | |
| CHEMBL584886 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL585191 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL567582 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL568438 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL579016 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL462360 | — | IC50 | > | 5000.0 | nM | - |