Assay Detail
Binding
CHEMBL1046492
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Inhibition of rat DNA polymerase beta by [3H]dTTP incorporation assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of dehydroaltenusin derivatives as selective DNA polymerase alpha inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.46 | 4.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL594272 | — | — | 1 | 4.96 |
| CHEMBL595189 | — | — | 1 | 4.62 |
| CHEMBL594951 | — | — | 1 | 4.46 |
| CHEMBL594151 | DEHYDROALTENUSIN | — | 1 | 4.19 |
| CHEMBL594273 | — | — | 1 | 4.05 |
| CHEMBL611034 | DESMETHYLDEHYDROALTENUSIN | — | 1 | - |
| CHEMBL593327 | — | — | 1 | - |
| CHEMBL593328 | — | — | 1 | - |
| CHEMBL595213 | — | — | 1 | - |
| CHEMBL595214 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL594272 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL595189 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL594951 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL594151 | DEHYDROALTENUSIN | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL594273 | — | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL611034 | DESMETHYLDEHYDROALTENUSIN | IC50 | = | 126000.0 | nM | - |
| CHEMBL593327 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL593328 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL595213 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL595214 | — | IC50 | > | 200000.0 | nM | - |