Assay Detail
Functional
CHEMBL1047075
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Might adrenergic alpha2C-agonists/alpha2A-antagonists become novel therapeutic tools for pain treatment with morphine?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.79 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL576078 | — | — | 1 | 7.60 |
| CHEMBL576623 | — | — | 1 | 7.40 |
| CHEMBL570973 | — | — | 1 | 7.30 |
| CHEMBL570863 | — | — | 1 | 7.20 |
| CHEMBL569933 | — | — | 1 | 6.81 |
| CHEMBL13852 | CIRAZOLINE | 2.0 | 1 | 6.40 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | 6.10 |
| CHEMBL576819 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL576078 | — | EC50 | = | 25.12 | nM | 7.60 |
| CHEMBL576623 | — | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL570973 | — | EC50 | = | 50.12 | nM | 7.30 |
| CHEMBL570863 | — | EC50 | = | 63.1 | nM | 7.20 |
| CHEMBL569933 | — | EC50 | = | 154.88 | nM | 6.81 |
| CHEMBL13852 | CIRAZOLINE | EC50 | = | 398.11 | nM | 6.40 |
| CHEMBL1437 | NOREPINEPHRINE | EC50 | = | 794.33 | nM | 6.10 |
| CHEMBL576819 | — | EC50 | = | 2884.03 | nM | 5.54 |