Assay Detail
Binding
CHEMBL1048032
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis, affinity profile and functional activity of potent chiral muscarinic antagonists with a pyrrolidinylfuran structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.51 | 9.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376897 | METHSCOPOLAMINE | 4.0 | 1 | 9.75 |
| CHEMBL569307 | — | — | 1 | 8.63 |
| CHEMBL571121 | — | — | 1 | 8.34 |
| CHEMBL583051 | — | — | 1 | 8.17 |
| CHEMBL569760 | — | — | 1 | 7.99 |
| CHEMBL583027 | — | — | 1 | 7.87 |
| CHEMBL569712 | — | — | 1 | 7.76 |
| CHEMBL568870 | — | — | 1 | 7.70 |
| CHEMBL576663 | — | — | 1 | 7.53 |
| CHEMBL569729 | — | — | 1 | 7.50 |
| CHEMBL571341 | — | — | 1 | 7.22 |
| CHEMBL571123 | — | — | 1 | 7.19 |
| CHEMBL568775 | — | — | 1 | 7.06 |
| CHEMBL576707 | — | — | 1 | 6.85 |
| CHEMBL569212 | — | — | 1 | 6.44 |
| CHEMBL569089 | — | — | 1 | 6.12 |
| CHEMBL569953 | — | — | 1 | 5.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376897 | METHSCOPOLAMINE | Ki | = | 0.1778 | nM | 9.75 |
| CHEMBL569307 | — | Ki | = | 2.344 | nM | 8.63 |
| CHEMBL571121 | — | Ki | = | 4.571 | nM | 8.34 |
| CHEMBL583051 | — | Ki | = | 6.761 | nM | 8.17 |
| CHEMBL569760 | — | Ki | = | 10.23 | nM | 7.99 |
| CHEMBL583027 | — | Ki | = | 13.49 | nM | 7.87 |
| CHEMBL569712 | — | Ki | = | 17.38 | nM | 7.76 |
| CHEMBL568870 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL576663 | — | Ki | = | 29.51 | nM | 7.53 |
| CHEMBL569729 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL571341 | — | Ki | = | 60.26 | nM | 7.22 |
| CHEMBL571123 | — | Ki | = | 64.57 | nM | 7.19 |
| CHEMBL568775 | — | Ki | = | 87.1 | nM | 7.06 |
| CHEMBL576707 | — | Ki | = | 141.25 | nM | 6.85 |
| CHEMBL569212 | — | Ki | = | 363.08 | nM | 6.44 |
| CHEMBL569089 | — | Ki | = | 758.58 | nM | 6.12 |
| CHEMBL569953 | — | Ki | = | 3235.94 | nM | 5.49 |