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Compound Detail

CHEMBL569307

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C[N+]1(C)CCC[C@@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1.[I-]

Basic Information

ChEMBL ID CHEMBL569307
Phase Preclinical
Structure Type MOL
InChI Key BEZNQWHLSZMASN-ZOLWKPHLSA-M
Parent Compound CHEMBL1197382
Active Moiety CHEMBL1197382
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names

Molecular Properties

354.5
MW (Da)
5.01
ALogP
2
HBA
1
HBD
33.4
PSA (Ų)
0.78
QED
1
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H32INO2
MW 481.42
Aromatic Rings 2
Heavy Atoms 26
NP-Likeness 0.47

Activity Summary

Ki 5 meas. best 9.16

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M1
CHEMBL216
Ki 9.16 9.16 0.7 1
Muscarinic acetylcholine receptor M3
CHEMBL245
Ki 8.82 8.82 1.5 1
Muscarinic acetylcholine receptor M5
CHEMBL2035
Ki 8.81 8.81 1.5 1
Muscarinic acetylcholine receptor M2
CHEMBL211
Ki 8.63 8.63 2.3 1
Muscarinic acetylcholine receptor M4
CHEMBL1821
Ki 8.37 8.37 4.3 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19928767 10.1021/jm901048j Muscarinic acetylcholine receptor M3 2
19928767 10.1021/jm901048j Muscarinic acetylcholine receptor M1 1
19928767 10.1021/jm901048j Muscarinic acetylcholine receptor M2 1
19928767 10.1021/jm901048j Muscarinic acetylcholine receptor M4 1
19928767 10.1021/jm901048j Muscarinic acetylcholine receptor M5 1
19928767 10.1021/jm901048j Unchecked 1
19928767 10.1021/jm901048j Muscarinic receptor 2 1
19928767 10.1021/jm901048j Muscarinic receptor 4 1

Data from ChEMBL 36 via Core Engine