Assay Detail
Binding
CHEMBL1048034
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]NMS from human cloned muscarinic M4 receptor expressed in CHO cells by scintillation counting
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Muscarinic acetylcholine receptor M4 (CHEMBL1821) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis, affinity profile and functional activity of potent chiral muscarinic antagonists with a pyrrolidinylfuran structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.30 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376897 | METHSCOPOLAMINE | 4.0 | 1 | 9.85 |
| CHEMBL571121 | — | — | 1 | 8.40 |
| CHEMBL569307 | — | — | 1 | 8.37 |
| CHEMBL583051 | — | — | 1 | 7.85 |
| CHEMBL569760 | — | — | 1 | 7.81 |
| CHEMBL569712 | — | — | 1 | 7.71 |
| CHEMBL568870 | — | — | 1 | 7.48 |
| CHEMBL583027 | — | — | 1 | 7.42 |
| CHEMBL571341 | — | — | 1 | 7.26 |
| CHEMBL569729 | — | — | 1 | 7.19 |
| CHEMBL576707 | — | — | 1 | 7.11 |
| CHEMBL576663 | — | — | 1 | 6.98 |
| CHEMBL571123 | — | — | 1 | 6.80 |
| CHEMBL568775 | — | — | 1 | 6.43 |
| CHEMBL569212 | — | — | 1 | 6.26 |
| CHEMBL569089 | — | — | 1 | 5.63 |
| CHEMBL569953 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376897 | METHSCOPOLAMINE | Ki | = | 0.1413 | nM | 9.85 |
| CHEMBL571121 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL569307 | — | Ki | = | 4.266 | nM | 8.37 |
| CHEMBL583051 | — | Ki | = | 14.13 | nM | 7.85 |
| CHEMBL569760 | — | Ki | = | 15.49 | nM | 7.81 |
| CHEMBL569712 | — | Ki | = | 19.5 | nM | 7.71 |
| CHEMBL568870 | — | Ki | = | 33.11 | nM | 7.48 |
| CHEMBL583027 | — | Ki | = | 38.02 | nM | 7.42 |
| CHEMBL571341 | — | Ki | = | 54.95 | nM | 7.26 |
| CHEMBL569729 | — | Ki | = | 64.57 | nM | 7.19 |
| CHEMBL576707 | — | Ki | = | 77.62 | nM | 7.11 |
| CHEMBL576663 | — | Ki | = | 104.71 | nM | 6.98 |
| CHEMBL571123 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL568775 | — | Ki | = | 371.54 | nM | 6.43 |
| CHEMBL569212 | — | Ki | = | 549.54 | nM | 6.26 |
| CHEMBL569089 | — | Ki | = | 2344.23 | nM | 5.63 |
| CHEMBL569953 | — | Ki | = | 3090.3 | nM | 5.51 |