Assay Detail
Binding
CHEMBL1048035
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]NMS from human cloned muscarinic M5 receptor expressed in CHO cells by scintillation counting
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Muscarinic acetylcholine receptor M5 (CHEMBL2035) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis, affinity profile and functional activity of potent chiral muscarinic antagonists with a pyrrolidinylfuran structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.49 | 9.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376897 | METHSCOPOLAMINE | 4.0 | 1 | 9.68 |
| CHEMBL569307 | — | — | 1 | 8.81 |
| CHEMBL571121 | — | — | 1 | 8.48 |
| CHEMBL583051 | — | — | 1 | 8.15 |
| CHEMBL569760 | — | — | 1 | 7.94 |
| CHEMBL568870 | — | — | 1 | 7.92 |
| CHEMBL569712 | — | — | 1 | 7.81 |
| CHEMBL571341 | — | — | 1 | 7.56 |
| CHEMBL583027 | — | — | 1 | 7.50 |
| CHEMBL569729 | — | — | 1 | 7.43 |
| CHEMBL576707 | — | — | 1 | 7.26 |
| CHEMBL576663 | — | — | 1 | 7.01 |
| CHEMBL571123 | — | — | 1 | 6.98 |
| CHEMBL568775 | — | — | 1 | 6.64 |
| CHEMBL569212 | — | — | 1 | 6.33 |
| CHEMBL569089 | — | — | 1 | 6.06 |
| CHEMBL569953 | — | — | 1 | 5.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376897 | METHSCOPOLAMINE | Ki | = | 0.2089 | nM | 9.68 |
| CHEMBL569307 | — | Ki | = | 1.549 | nM | 8.81 |
| CHEMBL571121 | — | Ki | = | 3.311 | nM | 8.48 |
| CHEMBL583051 | — | Ki | = | 7.079 | nM | 8.15 |
| CHEMBL569760 | — | Ki | = | 11.48 | nM | 7.94 |
| CHEMBL568870 | — | Ki | = | 12.02 | nM | 7.92 |
| CHEMBL569712 | — | Ki | = | 15.49 | nM | 7.81 |
| CHEMBL571341 | — | Ki | = | 27.54 | nM | 7.56 |
| CHEMBL583027 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL569729 | — | Ki | = | 37.15 | nM | 7.43 |
| CHEMBL576707 | — | Ki | = | 54.95 | nM | 7.26 |
| CHEMBL576663 | — | Ki | = | 97.72 | nM | 7.01 |
| CHEMBL571123 | — | Ki | = | 104.71 | nM | 6.98 |
| CHEMBL568775 | — | Ki | = | 229.09 | nM | 6.64 |
| CHEMBL569212 | — | Ki | = | 467.74 | nM | 6.33 |
| CHEMBL569089 | — | Ki | = | 870.96 | nM | 6.06 |
| CHEMBL569953 | — | Ki | = | 1548.82 | nM | 5.81 |