Assay Detail

CHEMBL1049171

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Functional

Cytotoxicity against human A2780 cells by MTT cell proliferation assay

ChEMBL ↗

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Target

A2780 (CHEMBL614004) ↗

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A2780 (CHEMBL614004) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target A2780

CHEMBL614004

Anchored from Assay target.

Protein identity A2780

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	A2780
Confidence	1 — Organism
Curated By	Autocuration

Target

A2780 (CHEMBL614004) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis.

Field JJ, Singh AJ, Kanakkanthara A, Halafihi T, Northcote PT, Miller JH.
J Med Chem (2009) 52 : 7328 -7332
PubMed 19877653 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.35	8.55

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL428647	PACLITAXEL	4.0	1	8.55
CHEMBL582439	ZAMPANOLIDE	—	1	8.15

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL428647	PACLITAXEL	IC50	=	2.8	nM	8.55
CHEMBL582439	ZAMPANOLIDE	IC50	=	7.1	nM	8.15