Assay Detail
Binding
CHEMBL1049174
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Inhibition of human recombinant MGL using 2-oleoylglycerol by competitive hydrolysis assay
13
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
beta-Lactams derived from a carbapenem chiron are selective inhibitors of human fatty acid amide hydrolase versus human monoacylglycerol lipase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.20 | 5.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL570127 | — | — | 2 | 5.74 |
| CHEMBL571724 | — | — | 2 | 5.73 |
| CHEMBL2151432 | — | — | 2 | 5.39 |
| CHEMBL570331 | — | — | 2 | 5.07 |
| CHEMBL585920 | — | — | 2 | 4.84 |
| CHEMBL576713 | — | — | 2 | 4.63 |
| CHEMBL560889 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL570127 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL570127 | — | IC50 | = | 1862.09 | nM | 5.73 |
| CHEMBL571724 | — | IC50 | = | 1862.09 | nM | 5.73 |
| CHEMBL2151432 | — | IC50 | = | 4073.8 | nM | 5.39 |
| CHEMBL2151432 | — | IC50 | = | 4060.0 | nM | 5.39 |
| CHEMBL571724 | — | IC50 | = | 4720.0 | nM | 5.33 |
| CHEMBL570331 | — | IC50 | = | 8510.0 | nM | 5.07 |
| CHEMBL570331 | — | IC50 | = | 8511.38 | nM | 5.07 |
| CHEMBL585920 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL585920 | — | IC50 | = | 14791.08 | nM | 4.83 |
| CHEMBL576713 | — | IC50 | = | 23300.0 | nM | 4.63 |
| CHEMBL576713 | — | IC50 | = | 23442.29 | nM | 4.63 |
| CHEMBL560889 | — | IC50 | = | 133000.0 | nM | - |