Compound Detail
CHEMBL571724
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Basic Information
| ChEMBL ID | CHEMBL571724 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CKWXNKGISRYRSO-OLZOCXBDSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
293.4
MW (Da)
2.23
ALogP
4
HBA
0
HBD
63.7
PSA (Ų)
0.28
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 CHEMBL2243 | IC50 | 7.5 | 7.5 | 31.6 | 2 |
| Monoglyceride lipase CHEMBL4191 | IC50 | 5.73 | 5.53 | 1862.1 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 | IC50 | = | 32.0 | nM | 7.5 | Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydroly... | 19877691 |
| Fatty-acid amide hydrolase 1 | IC50 | = | 31.62 | nM | 7.5 | Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydroly... | 19877691 |
| Monoglyceride lipase | IC50 | = | 1862.09 | nM | 5.73 | Inhibition of human recombinant MGL using 2-oleoylglycerol by competitive hydrol... | 19877691 |
| Monoglyceride lipase | IC50 | = | 4720.0 | nM | 5.33 | Inhibition of human recombinant MGL using 2-oleoylglycerol by competitive hydrol... | 19877691 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19877691 | 10.1021/jm9008532 | Monoglyceride lipase | 3 |
| 19877691 | 10.1021/jm9008532 | Fatty-acid amide hydrolase 1 | 2 |
Data from ChEMBL 36 via Core Engine