Assay Detail
Binding
CHEMBL1049243
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Inhibition of human serum AChE by Ellman's assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Active site directed docking studies: synthesis and pharmacological evaluation of cis-2,6-dimethyl piperidine sulfonamides as inhibitors of acetylcholinesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.66 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54126 | NEOSTIGMINE BROMIDE | 2.0 | 1 | 7.39 |
| CHEMBL576005 | — | — | 1 | 7.12 |
| CHEMBL582883 | — | — | 1 | 7.05 |
| CHEMBL575813 | — | — | 1 | 6.73 |
| CHEMBL574474 | — | — | 1 | 6.72 |
| CHEMBL573102 | — | — | 1 | 6.50 |
| CHEMBL575620 | — | — | 1 | 6.43 |
| CHEMBL575619 | — | — | 1 | 6.41 |
| CHEMBL575621 | — | — | 1 | 6.34 |
| CHEMBL574487 | — | — | 1 | 5.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54126 | NEOSTIGMINE BROMIDE | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL576005 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL582883 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL575813 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL574474 | — | IC50 | = | 192.0 | nM | 6.72 |
| CHEMBL573102 | — | IC50 | = | 318.0 | nM | 6.50 |
| CHEMBL575620 | — | IC50 | = | 368.0 | nM | 6.43 |
| CHEMBL575619 | — | IC50 | = | 392.0 | nM | 6.41 |
| CHEMBL575621 | — | IC50 | = | 458.0 | nM | 6.34 |
| CHEMBL574487 | — | IC50 | = | 1150.0 | nM | 5.94 |