Assay Detail
Functional
CHEMBL1049688
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Antiproliferative activity against human IGROV1 cells assessed as growth inhibition after 72 hrs by Coulter counting analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | IGROV-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Histone deacetylase and microtubules as targets for the synthesis of releasable conjugate compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.83 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18981 | THIOCOLCHICINE | — | 1 | 7.92 |
| CHEMBL566629 | — | — | 1 | 7.75 |
| CHEMBL567988 | — | — | 1 | 7.72 |
| CHEMBL298240 | — | — | 1 | 7.64 |
| CHEMBL570142 | — | — | 1 | 7.30 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.22 |
| CHEMBL572365 | — | — | 1 | 7.11 |
| CHEMBL305522 | CEPHALOMANNINE | — | 1 | 6.52 |
| CHEMBL566831 | — | — | 1 | 6.32 |
| CHEMBL568139 | — | — | 1 | 6.28 |
| CHEMBL587393 | — | — | 1 | 6.14 |
| CHEMBL577096 | — | — | 1 | 6.13 |
| CHEMBL566673 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18981 | THIOCOLCHICINE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL566629 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL567988 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL298240 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL570142 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL572365 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL305522 | CEPHALOMANNINE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL566831 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL568139 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL587393 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL577096 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL566673 | — | IC50 | = | 19100.0 | nM | 4.72 |