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Assay Detail

CHEMBL1049709

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Induction of Wistar rat peritoneal mast cell degradation assessed as concanavalin A-induced histamine release after 15 mins fluorometric assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Cell Type Mast cell
Confidence 1 — Organism
Curated By Autocuration

Target

Mast cell (CHEMBL613709)
Type CELL-LINE

Publication

Synthesis and evaluation of lysophosphatidylserine analogues as inducers of mast cell degranulation. Potent activities of lysophosphatidylthreonine and its 2-deoxy derivative.
Iwashita M, Makide K, Nonomura T, Misumi Y, Otani Y, Ishida M, Taguchi R, Tsujimoto M, Aoki J, Arai H, Ohwada T.
J Med Chem (2009) 52 : 5837 -5863
PubMed 19743861 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 23 6.20 7.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL566656 1 7.40
CHEMBL565817 1 7.40
CHEMBL571759 1 7.22
CHEMBL567937 1 7.00
CHEMBL579222 1 6.82
CHEMBL582985 1 6.40
CHEMBL567724 1 6.30
CHEMBL585320 1 6.00
CHEMBL585488 1 5.70
CHEMBL566055 1 5.70
CHEMBL568373 1 5.30
CHEMBL566035 1 5.30
CHEMBL565616 1 5.30
CHEMBL565816 1 5.00
CHEMBL584699 1 -
CHEMBL566465 1 -
CHEMBL585859 1 -
CHEMBL567096 1 -
CHEMBL584910 1 -
CHEMBL568352 1 -
CHEMBL566249 1 -
CHEMBL571316 1 -
CHEMBL566870 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL566656 EC50 = 40.0 nM 7.40
CHEMBL565817 EC50 = 40.0 nM 7.40
CHEMBL571759 EC50 = 60.0 nM 7.22
CHEMBL567937 EC50 = 100.0 nM 7.00
CHEMBL579222 EC50 = 150.0 nM 6.82
CHEMBL582985 EC50 = 400.0 nM 6.40
CHEMBL567724 EC50 = 500.0 nM 6.30
CHEMBL585320 EC50 = 1000.0 nM 6.00
CHEMBL585488 EC50 = 2000.0 nM 5.70
CHEMBL566055 EC50 = 2000.0 nM 5.70
CHEMBL568373 EC50 = 5000.0 nM 5.30
CHEMBL566035 EC50 = 5000.0 nM 5.30
CHEMBL565616 EC50 = 5000.0 nM 5.30
CHEMBL565816 EC50 = 10000.0 nM 5.00
CHEMBL584699 EC50 > 10000.0 nM -
CHEMBL566465 EC50 > 10000.0 nM -
CHEMBL585859 EC50 > 10000.0 nM -
CHEMBL567096 EC50 > 10000.0 nM -
CHEMBL584910 EC50 > 10000.0 nM -
CHEMBL568352 EC50 > 10000.0 nM -
CHEMBL566249 EC50 > 10000.0 nM -
CHEMBL571316 EC50 > 10000.0 nM -
CHEMBL566870 EC50 > 10000.0 nM -