Assay Detail
Binding
CHEMBL1051044
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Inhibition of SERT
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel, achiral aminoheterocycles as selective monoamine reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 8.16 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL570317 | — | — | 1 | 9.60 |
| CHEMBL1175 | DULOXETINE | 4.0 | 1 | 9.30 |
| CHEMBL560535 | — | — | 1 | 9.10 |
| CHEMBL564094 | — | — | 1 | 8.90 |
| CHEMBL561598 | — | — | 1 | 8.90 |
| CHEMBL550870 | — | — | 1 | 8.80 |
| CHEMBL551818 | — | — | 1 | 8.70 |
| CHEMBL564285 | — | — | 1 | 8.60 |
| CHEMBL550469 | — | — | 1 | 8.40 |
| CHEMBL557119 | — | — | 1 | 8.40 |
| CHEMBL552938 | — | — | 1 | 8.40 |
| CHEMBL552341 | — | — | 1 | 8.20 |
| CHEMBL564288 | — | — | 1 | 8.20 |
| CHEMBL560536 | — | — | 1 | 8.20 |
| CHEMBL556714 | — | — | 1 | 7.90 |
| CHEMBL551135 | — | — | 1 | 7.70 |
| CHEMBL555565 | — | — | 1 | 7.60 |
| CHEMBL556299 | — | — | 1 | 7.50 |
| CHEMBL561599 | — | — | 1 | 7.40 |
| CHEMBL571893 | — | — | 1 | 7.40 |
| CHEMBL550932 | — | — | 1 | 6.40 |
| CHEMBL559137 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL570317 | — | Ki | = | 0.2512 | nM | 9.60 |
| CHEMBL1175 | DULOXETINE | Ki | = | 0.5012 | nM | 9.30 |
| CHEMBL560535 | — | Ki | = | 0.7943 | nM | 9.10 |
| CHEMBL564094 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL561598 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL550870 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL551818 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL564285 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL550469 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL557119 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL552938 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL552341 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL564288 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL560536 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL556714 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL551135 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL555565 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL556299 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL561599 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL571893 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL550932 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL559137 | — | Ki | = | 1000.0 | nM | 6.00 |