Assay Detail
Functional
CHEMBL1051576
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Antagonist activity at vasopressin V1a receptor in phenoxybenzamine-treated Wistar rat uterus assessed as inhibition of vasopressin-induced arterial vasopressor activity treated 1 min prior to vasopressin challenge
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Uterus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Arginine vasopressin and its analogues--the influence of position 2 modification with 3,3-diphenylalanine enantiomers. Highly potent V2 agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 6.94 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL553710 | — | — | 1 | 8.35 |
| CHEMBL558950 | — | — | 1 | 7.40 |
| CHEMBL538934 | — | — | 1 | 6.20 |
| CHEMBL541246 | — | — | 1 | 5.80 |
| CHEMBL555452 | — | — | 1 | - |
| CHEMBL540754 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL553710 | — | Kd | = | 4.467 | nM | 8.35 |
| CHEMBL558950 | — | Kd | = | 39.81 | nM | 7.40 |
| CHEMBL538934 | — | Kd | = | 630.96 | nM | 6.20 |
| CHEMBL541246 | — | Kd | = | 1584.89 | nM | 5.80 |
| CHEMBL555452 | — | Kd | > | 1584.89 | nM | - |
| CHEMBL540754 | — | Kd | > | 1584.89 | nM | - |