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Compound Detail

CHEMBL538934

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N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O

Basic Information

ChEMBL ID CHEMBL538934
Phase Preclinical
Structure Type MOL
InChI Key HGNJZHKQNIASIY-MIKGUVKESA-N
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

1129.3
MW (Da)

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C52H68N14O11S2
MW 1129.34

Activity Summary

Kd 3 meas. best 7.8

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Oxytocin receptor
CHEMBL3996
Kd 7.8 7.5 15.8 2
Vasopressin V1a receptor
CHEMBL2868
Kd 6.2 6.2 631.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19418631 10.1016/j.ejmech.2008.12.010 Rattus norvegicus 11
19418631 10.1016/j.ejmech.2008.12.010 Oxytocin receptor 2
19418631 10.1016/j.ejmech.2008.12.010 Vasopressin V1a receptor 1

Data from ChEMBL 36 via Core Engine