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Assay Detail

CHEMBL1051621

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Antiplasmodial isoflavanones from the roots of Sophora mollis.
Zhang GP, Xiao ZY, Rafique J, Arfan M, Smith PJ, Lategan CA, Hu LH.
J Nat Prod (2009) 72 : 1265 -1268
PubMed 19572738 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 5.36 10.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL76 CHLOROQUINE 4.0 1 10.40
CHEMBL557703 SOPHONOROL C 1 4.89
CHEMBL557704 SOPHONOROL E 1 4.89
CHEMBL242739 1 4.75
CHEMBL301624 1 4.71
CHEMBL129795 ISOLIQUIRITIGENIN 1 4.50
CHEMBL558301 SOPHONOROL F 1 4.39
CHEMBL565053 ECHINOISOFLAVANONE 1 4.38
CHEMBL563182 SOPHORONOL A 1 -
CHEMBL552109 SOPHORONOL B 1 -
CHEMBL71851 SCOPOLETIN 1 -
CHEMBL445279 (+)-MAACKIAIN 1 -
CHEMBL550446 SOPHORONOL 1 -
CHEMBL549957 SOPHONOROL D 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL76 CHLOROQUINE IC50 = 0.04 nM 10.40
CHEMBL557703 SOPHONOROL C IC50 = 12900.0 nM 4.89
CHEMBL557704 SOPHONOROL E IC50 = 12800.0 nM 4.89
CHEMBL242739 IC50 = 17800.0 nM 4.75
CHEMBL301624 IC50 = 19300.0 nM 4.71
CHEMBL129795 ISOLIQUIRITIGENIN IC50 = 32000.0 nM 4.50
CHEMBL558301 SOPHONOROL F IC50 = 41000.0 nM 4.39
CHEMBL565053 ECHINOISOFLAVANONE IC50 = 42100.0 nM 4.38
CHEMBL563182 SOPHORONOL A IC50 - -
CHEMBL552109 SOPHORONOL B IC50 - -
CHEMBL71851 SCOPOLETIN IC50 = 493600.0 nM -
CHEMBL445279 (+)-MAACKIAIN IC50 = 177000.0 nM -
CHEMBL550446 SOPHORONOL IC50 = 114500.0 nM -
CHEMBL549957 SOPHONOROL D IC50 = 105600.0 nM -