Assay Detail
Functional
CHEMBL1053102
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Antiproliferative activity against JAK3 expressing human resting Jurkat cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthetic staurosporines via a ring closing metathesis strategy as potent JAK3 inhibitors and modulators of allergic responses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.63 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 6.51 |
| CHEMBL558241 | — | — | 1 | 6.21 |
| CHEMBL557559 | — | — | 1 | 5.80 |
| CHEMBL562934 | — | — | 1 | 5.25 |
| CHEMBL558115 | — | — | 1 | 5.00 |
| CHEMBL559787 | — | — | 1 | 5.00 |
| CHEMBL557846 | — | — | 1 | - |
| CHEMBL563588 | — | — | 1 | - |
| CHEMBL565066 | — | — | 1 | - |
| CHEMBL557101 | — | — | 1 | - |
| CHEMBL564940 | — | — | 1 | - |
| CHEMBL550791 | — | — | 1 | - |
| CHEMBL16958 | STAUROSPORINONE | — | 1 | - |
| CHEMBL563795 | — | — | 1 | - |
| CHEMBL557709 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 311.0 | nM | 6.51 |
| CHEMBL558241 | — | IC50 | = | 616.0 | nM | 6.21 |
| CHEMBL557559 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL562934 | — | IC50 | = | 5670.0 | nM | 5.25 |
| CHEMBL558115 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL559787 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL557846 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL563588 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL565066 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL557101 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL564940 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL550791 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL16958 | STAUROSPORINONE | IC50 | - | — | - | |
| CHEMBL563795 | — | IC50 | - | — | - | |
| CHEMBL557709 | — | IC50 | > | 10000.0 | nM | - |