Assay Detail
Binding
CHEMBL1053955
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human carbonic anhydrase 5A by stopped flow CO2 hydration assay
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Carbonic anhydrase 5A, mitochondrial (CHEMBL4789) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian alpha-carbonic anhydrase isoforms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.72 | 7.20 |
| IC50 | 1 | 5.02 | 5.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.20 |
| CHEMBL255863 | NILOTINIB | 4.0 | 1 | 5.26 |
| CHEMBL560175 | — | — | 1 | 5.02 |
| CHEMBL941 | IMATINIB | 4.0 | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL255863 | NILOTINIB | Ki | = | 5485.0 | nM | 5.26 |
| CHEMBL560175 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL941 | IMATINIB | Ki | = | 20200.0 | nM | 4.70 |