Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1055012

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]deltorphin 2 from delta opioid receptor in Sprague-Dawley rat brain P2 synaptosomal membrane
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Delta-type opioid receptor (CHEMBL269)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Influence of the side chain next to C-terminal benzimidazole in opioid pseudopeptides containing the Dmt-Tic pharmacophore.
Balboni G, Trapella C, Sasaki Y, Ambo A, Marczak ED, Lazarus LH, Salvadori S.
J Med Chem (2009) 52 : 5556 -5559
PubMed 19642675 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 18 9.43 10.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL557346 1 10.46
CHEMBL556230 1 10.46
CHEMBL540724 1 10.40
CHEMBL556063 1 10.31
CHEMBL538699 1 10.29
CHEMBL551937 1 10.20
CHEMBL564083 1 10.19
CHEMBL539386 1 10.09
CHEMBL538384 1 9.87
CHEMBL554838 1 9.86
CHEMBL553461 1 9.75
CHEMBL538457 1 9.74
CHEMBL540972 1 9.35
CHEMBL554625 1 9.34
CHEMBL538456 1 9.31
CHEMBL559088 1 9.19
CHEMBL553221 1 5.68
CHEMBL563304 1 5.22

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL557346 Ki = 0.035 nM 10.46
CHEMBL556230 Ki = 0.035 nM 10.46
CHEMBL540724 Ki = 0.04 nM 10.40
CHEMBL556063 Ki = 0.049 nM 10.31
CHEMBL538699 Ki = 0.051 nM 10.29
CHEMBL551937 Ki = 0.063 nM 10.20
CHEMBL564083 Ki = 0.065 nM 10.19
CHEMBL539386 Ki = 0.082 nM 10.09
CHEMBL538384 Ki = 0.135 nM 9.87
CHEMBL554838 Ki = 0.138 nM 9.86
CHEMBL553461 Ki = 0.179 nM 9.75
CHEMBL538457 Ki = 0.18 nM 9.74
CHEMBL540972 Ki = 0.443 nM 9.35
CHEMBL554625 Ki = 0.457 nM 9.34
CHEMBL538456 Ki = 0.49 nM 9.31
CHEMBL559088 Ki = 0.64 nM 9.19
CHEMBL553221 Ki = 2100.0 nM 5.68
CHEMBL563304 Ki = 6085.0 nM 5.22