Assay Detail
Functional
CHEMBL1056006
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Cytotoxicity against human DU145 cells after 72 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
1,8-Naphthyridine-3-carboxamide derivatives with anticancer and anti-inflammatory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.60 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.00 |
| CHEMBL560008 | — | — | 1 | 6.22 |
| CHEMBL549515 | — | — | 1 | 5.77 |
| CHEMBL564313 | — | — | 1 | 5.68 |
| CHEMBL560007 | — | — | 1 | 5.50 |
| CHEMBL557732 | — | — | 1 | 5.31 |
| CHEMBL563762 | — | — | 1 | 5.23 |
| CHEMBL556924 | — | — | 1 | 5.14 |
| CHEMBL564247 | — | — | 1 | 5.09 |
| CHEMBL562008 | — | — | 1 | 5.06 |
| CHEMBL560282 | — | — | 1 | - |
| CHEMBL552422 | — | — | 1 | - |
| CHEMBL558069 | — | — | 1 | - |
| CHEMBL563756 | — | — | 1 | - |
| CHEMBL557872 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL560008 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL549515 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL564313 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL560007 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL557732 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL563762 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL556924 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL564247 | — | IC50 | = | 8030.0 | nM | 5.09 |
| CHEMBL562008 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL560282 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL552422 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL558069 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL563756 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL557872 | — | IC50 | > | 10000.0 | nM | - |