Assay Detail
ADMET
CHEMBL1056549
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Inhibition of human CYP2D6 by fluorescence-based assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl) benzamide (ADL5747).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 5.44 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL551412 | — | — | 1 | 7.05 |
| CHEMBL550063 | — | — | 1 | 6.36 |
| CHEMBL550669 | — | — | 1 | 6.19 |
| CHEMBL563137 | — | — | 1 | 6.17 |
| CHEMBL551536 | — | — | 1 | 6.00 |
| CHEMBL551413 | — | — | 1 | 5.92 |
| CHEMBL551613 | — | — | 1 | 5.75 |
| CHEMBL550472 | — | — | 1 | 5.68 |
| CHEMBL563700 | — | — | 1 | 5.66 |
| CHEMBL556439 | — | — | 1 | 5.62 |
| CHEMBL563893 | — | — | 1 | 5.58 |
| CHEMBL561805 | — | — | 1 | 5.55 |
| CHEMBL551615 | — | — | 1 | 5.55 |
| CHEMBL550471 | — | — | 1 | 5.51 |
| CHEMBL561882 | — | — | 1 | 5.39 |
| CHEMBL494462 | — | — | 1 | 5.37 |
| CHEMBL550261 | — | — | 1 | 5.36 |
| CHEMBL562478 | — | — | 1 | 5.34 |
| CHEMBL564922 | — | — | 1 | 5.33 |
| CHEMBL562873 | — | — | 1 | 5.28 |
| CHEMBL562898 | — | — | 1 | 5.24 |
| CHEMBL557121 | — | — | 1 | 5.21 |
| CHEMBL556648 | — | — | 1 | 5.15 |
| CHEMBL551414 | — | — | 1 | 5.12 |
| CHEMBL559414 | — | — | 1 | 5.12 |
| CHEMBL557257 | — | — | 1 | 5.02 |
| CHEMBL557458 | — | — | 1 | 5.02 |
| CHEMBL562280 | — | — | 1 | 4.68 |
| CHEMBL557054 | — | — | 1 | 4.52 |
| CHEMBL561138 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL551412 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL550063 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL550669 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL563137 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL551536 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL551413 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL551613 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL550472 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL563700 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL556439 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL563893 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL561805 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL551615 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL550471 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL561882 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL494462 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL550261 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL562478 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL564922 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL562873 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL562898 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL557121 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL556648 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL551414 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL559414 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL557257 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL557458 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL562280 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL557054 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL561138 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL561339 | ADL-5747 FREE BASE | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL556923 | — | IC50 | - | — | - |