Assay Detail

CHEMBL1057071

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Functional

Agonist activity at adrenergic beta2 receptor in Hartley guinea pig tracheal ring assessed as bronchorelaxation activity against carbachol-induced contraction

ChEMBL ↗

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Target

Beta-2 adrenergic receptor (CHEMBL5414) ↗

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Beta-2 adrenergic receptor (CHEMBL5414) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Beta-2 adrenergic receptor

CHEMBL5414

Anchored from Assay target.

Protein identity Beta-2 adrenergic receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Cavia porcellus
Tissue	Trachea
Confidence	9 — Direct single protein target
Curated By	Intermediate

Target

Beta-2 adrenergic receptor (CHEMBL5414) ↗

Type	SINGLE PROTEIN
Organism	Cavia porcellus

Publication

Synthesis, pharmacological and in silico evaluation of 1-(4-di-hydroxy-3,5-dioxa-4-borabicyclo[4.4.0]deca-7,9,11-trien-9-yl)-2-(tert-butylamino)ethanol, a compound designed to act as a beta2 adrenoceptor agonist.

Soriano-Ursúa MA, Valencia-Hernández I, Arellano-Mendoza MG, Correa-Basurto J, Trujillo-Ferrara JG.
Eur J Med Chem (2009) 44 : 2840 -2846
PubMed 19168263 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Activity	2	-	-
EC50	2	7.63	8.68

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL552398	—	—	2	8.68
CHEMBL714	ALBUTEROL	4.0	2	6.57

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL552398	—	EC50	=	2.097	nM	8.68
CHEMBL714	ALBUTEROL	EC50	=	268.0	nM	6.57
CHEMBL552398	—	Activity		-	—	-
CHEMBL714	ALBUTEROL	Activity		-	—	-