Compound Detail
CHEMBL552398
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Basic Information
| ChEMBL ID | CHEMBL552398 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AXCRPUQPHZRZNF-LLVKDONJSA-N |
1
Targets
3
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
283.1
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 10.14
Kd 1 meas. best 6.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Beta-2 adrenergic receptor CHEMBL5414 | EC50 | 10.14 | 9.41 | 0.1 | 2 |
| Beta-2 adrenergic receptor CHEMBL5414 | Kd | 6.96 | 6.96 | 110.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Beta-2 adrenergic receptor | EC50 | = | 0.072 | nM | 10.14 | Agonist activity at adrenergic beta2 receptor in Hartley guinea pig tracheal rin... | 19168263 |
| Beta-2 adrenergic receptor | EC50 | = | 2.097 | nM | 8.68 | Agonist activity at adrenergic beta2 receptor in Hartley guinea pig tracheal rin... | 19168263 |
| Beta-2 adrenergic receptor | Kd | = | 110.0 | nM | 6.96 | Binding affinity to adrenergic beta2 receptor in Hartley guinea pig tracheal rin... | 19168263 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19168263 | 10.1016/j.ejmech.2008.12.016 | Beta-2 adrenergic receptor | 9 |
Data from ChEMBL 36 via Core Engine