Assay Detail
Functional
CHEMBL1058641
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human LNCAP cells after 3 days by MTS assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.01 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL550972 | — | — | 1 | 8.82 |
| CHEMBL551440 | — | — | 1 | 8.52 |
| CHEMBL552532 | — | — | 1 | 7.96 |
| CHEMBL564404 | — | — | 1 | 7.55 |
| CHEMBL538378 | — | — | 1 | 7.51 |
| CHEMBL563985 | — | — | 1 | 7.51 |
| CHEMBL562999 | — | — | 1 | 7.38 |
| CHEMBL561907 | — | — | 1 | 7.28 |
| CHEMBL550286 | — | — | 1 | 7.28 |
| CHEMBL558486 | — | — | 1 | 7.26 |
| CHEMBL557963 | — | — | 1 | 7.22 |
| CHEMBL561844 | — | — | 1 | 7.18 |
| CHEMBL540695 | — | — | 1 | 6.82 |
| CHEMBL562439 | — | — | 1 | 6.71 |
| CHEMBL561103 | — | — | 1 | 6.67 |
| CHEMBL561708 | — | — | 1 | 6.45 |
| CHEMBL564099 | — | — | 1 | 6.13 |
| CHEMBL562365 | — | — | 1 | 6.09 |
| CHEMBL551442 | — | — | 1 | 5.86 |
| CHEMBL558288 | — | — | 1 | 5.59 |
| CHEMBL562165 | — | — | 1 | 5.47 |
| CHEMBL556947 | — | — | 1 | - |
| CHEMBL558955 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL550972 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL551440 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL552532 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL564404 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL538378 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL563985 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL562999 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL561907 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL550286 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL558486 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL557963 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL561844 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL540695 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL562439 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL561103 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL561708 | — | IC50 | = | 355.0 | nM | 6.45 |
| CHEMBL564099 | — | IC50 | = | 733.0 | nM | 6.13 |
| CHEMBL562365 | — | IC50 | = | 817.0 | nM | 6.09 |
| CHEMBL551442 | — | IC50 | = | 1367.0 | nM | 5.86 |
| CHEMBL558288 | — | IC50 | = | 2567.0 | nM | 5.59 |
| CHEMBL562165 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL556947 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL558955 | — | IC50 | < | 1.0 | nM | - |