Assay Detail
Binding
CHEMBL1058948
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to muscarinic M1 receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinol esters as potent and long-acting muscarinic antagonists with potential for minimal systemic exposure after inhaled administration: identification of (3R)-3-{[hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide (aclidinium bromide).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 9.80 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL564057 | — | — | 1 | 10.10 |
| CHEMBL551466 | ACLIDINIUM BROMIDE | 4.0 | 1 | 10.10 |
| CHEMBL556635 | — | — | 1 | 10.05 |
| CHEMBL3545181 | TIOTROPIUM BROMIDE | 4.0 | 1 | 9.92 |
| CHEMBL1908368 | — | — | 1 | 8.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL564057 | — | Ki | = | 0.08 | nM | 10.10 |
| CHEMBL551466 | ACLIDINIUM BROMIDE | Ki | = | 0.08 | nM | 10.10 |
| CHEMBL556635 | — | Ki | = | 0.09 | nM | 10.05 |
| CHEMBL3545181 | TIOTROPIUM BROMIDE | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL1908368 | — | Ki | = | 1.51 | nM | 8.82 |