Assay Detail
Binding
CHEMBL1059320
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PIM3 by scintillation counting
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Serine/threonine-protein kinase pim-3 (CHEMBL5407) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as potent, highly selective, and orally bioavailable inhibitors of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM) kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 8.94 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL576387 | — | — | 1 | 9.70 |
| CHEMBL583273 | — | — | 1 | 9.52 |
| CHEMBL572781 | — | — | 1 | 9.52 |
| CHEMBL583187 | — | — | 1 | 9.40 |
| CHEMBL585182 | — | — | 1 | 9.30 |
| CHEMBL582844 | — | — | 1 | 9.15 |
| CHEMBL572550 | — | — | 1 | 9.05 |
| CHEMBL573702 | — | — | 1 | 9.00 |
| CHEMBL584161 | — | — | 1 | 8.40 |
| CHEMBL583144 | — | — | 1 | 7.96 |
| CHEMBL573929 | — | — | 1 | 7.37 |
| CHEMBL573012 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL576387 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL583273 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL572781 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL583187 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL585182 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL582844 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL572550 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL573702 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL584161 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL583144 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL573929 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL573012 | — | Ki | < | 0.1 | nM | - |