Compound Detail
CHEMBL573702
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL573702 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PZACVAVZCMGALO-UHFFFAOYSA-N |
4
Targets
4
Activities
2
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
360.4
MW (Da)
3.74
ALogP
5
HBA
1
HBD
72.8
PSA (Ų)
0.60
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 9.0
EC50 1 meas. best 5.39
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-3 CHEMBL5407 | Ki | 9.0 | 9.0 | 1.0 | 1 |
| Serine/threonine-protein kinase pim-1 CHEMBL2147 | Ki | 8.3 | 8.3 | 5.0 | 1 |
| Serine/threonine-protein kinase pim-2 CHEMBL4523 | Ki | 7.68 | 7.68 | 21.0 | 1 |
| MV4-11 CHEMBL613835 | EC50 | 5.39 | 5.39 | 4100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-3 | Ki | = | 1.0 | nM | 9.0 | Inhibition of human PIM3 by scintillation counting | 19842661 |
| Serine/threonine-protein kinase pim-1 | Ki | = | 5.0 | nM | 8.3 | Inhibition of human PIM1 by scintillation counting | 19842661 |
| Serine/threonine-protein kinase pim-2 | Ki | = | 21.0 | nM | 7.68 | Inhibition of human PIM2 by scintillation counting | 19842661 |
| MV4-11 | EC50 | = | 4100.0 | nM | 5.39 | Antiproliferative activity against human MV4-11 cells after 48 hrs by alamar blu... | 19842661 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19842661 | 10.1021/jm900943h | Serine/threonine-protein kinase pim-1 | 1 |
| 19842661 | 10.1021/jm900943h | Serine/threonine-protein kinase pim-2 | 1 |
| 19842661 | 10.1021/jm900943h | Serine/threonine-protein kinase pim-3 | 1 |
| 19842661 | 10.1021/jm900943h | K562 | 1 |
| 19842661 | 10.1021/jm900943h | MV4-11 | 1 |
Data from ChEMBL 36 via Core Engine