Assay Detail
Functional
CHEMBL1062146
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Anticancer activity against human DU145 cells after 72 hrs by SRB assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antitumor agents 268. Design, synthesis, and mechanistic studies of new 9-substituted phenanthrene-based tylophorine analogues as potent cytotoxic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.09 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL228286 | (-)-ANTOFINE | — | 1 | 7.60 |
| CHEMBL550974 | — | — | 1 | 6.96 |
| CHEMBL551847 | — | — | 1 | 6.96 |
| CHEMBL563209 | — | — | 1 | 6.80 |
| CHEMBL231594 | — | — | 1 | 6.62 |
| CHEMBL562107 | — | — | 1 | 6.58 |
| CHEMBL3216430 | — | — | 1 | 6.46 |
| CHEMBL3217114 | — | — | 1 | 6.11 |
| CHEMBL3215767 | — | — | 1 | 6.09 |
| CHEMBL551163 | — | — | 1 | 6.08 |
| CHEMBL561303 | — | — | 1 | 6.03 |
| CHEMBL558289 | — | — | 1 | 5.99 |
| CHEMBL551159 | — | — | 1 | 5.97 |
| CHEMBL550492 | — | — | 1 | 5.96 |
| CHEMBL559831 | — | — | 1 | 5.96 |
| CHEMBL563775 | — | — | 1 | 5.82 |
| CHEMBL563448 | — | — | 1 | 5.73 |
| CHEMBL562839 | — | — | 1 | 5.57 |
| CHEMBL3217111 | — | — | 1 | 5.02 |
| CHEMBL563973 | — | — | 1 | 4.90 |
| CHEMBL564127 | — | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL228286 | (-)-ANTOFINE | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL550974 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL551847 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL563209 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL231594 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL562107 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3216430 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL3217114 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL3215767 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL551163 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL561303 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL558289 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL551159 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL550492 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL559831 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL563775 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL563448 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL562839 | — | IC50 | = | 2680.0 | nM | 5.57 |
| CHEMBL3217111 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL563973 | — | IC50 | = | 12560.0 | nM | 4.90 |
| CHEMBL564127 | — | IC50 | = | 17230.0 | nM | 4.76 |