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Assay Detail

CHEMBL1063135

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Binding
Inhibition of rabbit muscle glycogen phosphorylase b
28
Total Activities
28
Compounds Tested
3
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Oryctolagus cuniculus
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Glycogen phosphorylase, muscle form (CHEMBL4696)
Type SINGLE PROTEIN
Organism Oryctolagus cuniculus

Publication

Synthesis and structure-activity relationships of C-glycosylated oxadiazoles as inhibitors of glycogen phosphorylase.
Tóth M, Kun S, Bokor E, Benltifa M, Tallec G, Vidal S, Docsa T, Gergely P, Somsák L, Praly JP.
Bioorg Med Chem (2009) 17 : 4773 -4785
PubMed 19450985 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 22 4.96 6.46
IC50 5 - -
Inhibition 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL490001 1 6.46
CHEMBL564199 1 5.64
CHEMBL549843 1 5.62
CHEMBL554821 1 5.48
CHEMBL489799 1 5.34
CHEMBL556336 1 5.22
CHEMBL552199 1 5.20
CHEMBL549702 1 5.06
CHEMBL558445 1 5.05
CHEMBL488967 1 5.00
CHEMBL490000 1 4.82
CHEMBL558444 1 4.72
CHEMBL549436 1 4.71
CHEMBL556286 1 4.69
CHEMBL3351143 1 4.50
CHEMBL560324 1 4.42
CHEMBL549701 1 4.19
CHEMBL559793 1 4.12
CHEMBL3351140 1 4.09
CHEMBL557649 1 -
CHEMBL549434 1 -
CHEMBL559671 1 -
CHEMBL540929 1 -
CHEMBL443455 1 -
CHEMBL563048 1 -
CHEMBL539944 1 -
CHEMBL450104 1 -
CHEMBL537942 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL490001 Ki = 350.0 nM 6.46
CHEMBL564199 Ki = 2300.0 nM 5.64
CHEMBL549843 Ki = 2400.0 nM 5.62
CHEMBL554821 Ki = 3300.0 nM 5.48
CHEMBL489799 Ki = 4600.0 nM 5.34
CHEMBL556336 Ki = 6000.0 nM 5.22
CHEMBL552199 Ki = 6300.0 nM 5.20
CHEMBL549702 Ki = 8800.0 nM 5.06
CHEMBL558445 Ki = 9000.0 nM 5.05
CHEMBL488967 Ki = 10000.0 nM 5.00
CHEMBL490000 Ki = 15000.0 nM 4.82
CHEMBL558444 Ki = 19000.0 nM 4.72
CHEMBL549436 Ki = 19400.0 nM 4.71
CHEMBL556286 Ki = 20400.0 nM 4.69
CHEMBL3351143 Ki = 32000.0 nM 4.50
CHEMBL560324 Ki = 38000.0 nM 4.42
CHEMBL549701 Ki = 64000.0 nM 4.19
CHEMBL559793 Ki = 76000.0 nM 4.12
CHEMBL3351140 Ki = 81000.0 nM 4.09
CHEMBL557649 IC50 = 550000.0 nM -
CHEMBL549434 IC50 = 650000.0 nM -
CHEMBL559671 IC50 = 350000.0 nM -
CHEMBL540929 Ki = 145000.0 nM -
CHEMBL443455 Ki = 305000.0 nM -
CHEMBL563048 IC50 > 625000.0 nM -
CHEMBL539944 Inhibition - % -
CHEMBL450104 Ki = 444000.0 nM -
CHEMBL537942 IC50 = 4500000.0 nM -